Description
Composition (Each Tablet Contains):
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Leflunomide – 20 mg
Form: Oral Tablet
Pack Size: 10×10 Alu-Alu
Product Description:
DEFLUMIDE® 20 mg contains Leflunomide, a powerful immunomodulatory agent used in the long-term management of rheumatoid arthritis and psoriatic arthritis. It works by selectively inhibiting pyrimidine synthesis in immune cells, which slows disease progression and reduces joint inflammation, stiffness, and pain.
DEFLUMIDE® helps preserve joint function, reduce structural damage, and improve mobility and quality of life in patients with autoimmune arthritis.
Key Benefits:
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Slows disease progression in rheumatoid and psoriatic arthritis
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Reduces joint pain, swelling, and morning stiffness
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Preserves joint structure and function with continued use
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May reduce the need for corticosteroids or NSAIDs
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Ideal for long-term management of autoimmune joint conditions
How It Works:
Leflunomide inhibits the enzyme dihydroorotate dehydrogenase (DHODH) in activated lymphocytes, blocking pyrimidine synthesis. This reduces autoimmune activity and inflammatory cytokines, helping control the systemic and joint-specific manifestations of rheumatoid arthritis.
How to Use:
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Typically prescribed as 1 tablet (20 mg) once daily
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Take after meals to improve gastrointestinal tolerance
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Swallow whole with water — do not crush or chew
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Follow your doctor’s dosage and tapering guidelines
Safety Advice:
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Regularly monitor liver function tests, blood pressure, and CBC
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Avoid live vaccines during treatment
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Women of childbearing age should use effective contraception
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Discuss alcohol use with your doctor to reduce liver strain
Precautions:
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Not recommended in pregnancy or planning-to-conceive patients
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Contraindicated in patients with severe hepatic impairment or immunodeficiency
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Use cautiously in patients with lung disorders, hypertension, or renal dysfunction
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Discontinue immediately if serious infection or severe rash occurs
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