IVERDEL® – FORTE Injection

Description

Composition (Per Vial):

• Cefepime – 1 g

• Amikacin – 250 mg

• L-Arginine – 370 mg
  Form: Sterile powder for reconstitution
  Route of Administration: Intravenous (IV) use only
  Pack Size: Single-use vial
  Category: Antibiotic Combination | ICU Sepsis Care | Renal-Sparing Injectable

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Product Description:

IVERDEL® – FORTE is a powerful triple-action formulation combining Cefepime, a fourth-generation cephalosporin; Amikacin, a potent aminoglycoside; and L-Arginine, a renal-protective amino acid. This unique combination is designed for critically ill patients, especially those battling severe Gram-negative and mixed bacterial infections.

It is particularly useful in managing ICU sepsis, hospital-acquired pneumonia, urinary tract infections, surgical site infections, and febrile neutropenia, while supporting renal protection during aminoglycoside therapy.

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Key Benefits:

• Broad-spectrum coverage: Active against both Gram-positive and Gram-negative bacteria

• Effective in multi-drug resistant infections, especially Pseudomonas & Enterobacter

• Renal support: L-Arginine helps reduce nephrotoxicity risk from aminoglycosides

• Ideal for high-risk ICU patients, including immunocompromised and post-surgical cases

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How It Works:

• Cefepime disrupts bacterial cell wall synthesis by binding to PBP (Penicillin-Binding Proteins), leading to cell lysis

• Amikacin inhibits bacterial protein synthesis at the 30S ribosomal subunit, causing irreversible bacterial death

• L-Arginine improves renal blood flow, supports nitric oxide production, and helps protect kidney tissue from aminoglycoside-induced toxicity

Together, they create a potent bactericidal effect with added nephroprotection.

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How to Use:

• Reconstitute with the provided sterile water

• Administer via slow IV infusion over 30–60 minutes

• Typical adult dosage: As per physician’s discretion, based on infection type and renal function

• To be used strictly under medical supervision in hospital settings

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Safety Advice:

• Adjust dosage in patients with renal impairment (monitor serum creatinine)

• Monitor for signs of ototoxicity and nephrotoxicity during prolonged use

• Avoid combining with other nephrotoxic drugs without clear indication

• Periodic audiometry and renal function tests recommended in long-term therapy

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Precautions:

• Not for intramuscular or bolus IV use

• Contraindicated in patients with hypersensitivity to cephalosporins or aminoglycosides

• Use with caution in pregnant or lactating women unless clearly needed

• Observe for hypersensitivity reactions, especially in patients with penicillin allergy

• Use immediately after reconstitution or refrigerate and use within 24 hours