TELVICTOR® – 400mg Injection

Description

Composition (Per Vial):

• Teicoplanin – 400 mg (lyophilized powder)
  Route of Administration: Intravenous (IV) or Intramuscular (IM)
  Form: Sterile, lyophilized powder for reconstitution
  Pack Size: Single-dose vial
  Category: Glycopeptide Antibiotic | MRSA Coverage | Hospital Use

---

Product Description:

TELVICTOR® – 400mg Injection contains Teicoplanin, a long-acting glycopeptide antibiotic used in the treatment of severe Gram-positive bacterial infections, including MRSA, Streptococcal, Enterococcal, and Staphylococcal infections.

It is widely used in hospital-acquired infections, skin and soft tissue infections, bone and joint infections, bacteremia, and infective endocarditis. Its prolonged half-life enables once-daily dosing and makes it a preferred option over vancomycin in several clinical scenarios due to less nephrotoxicity.

---

Key Benefits:

• Effective against MRSA and resistant Gram-positive organisms

• Can be administered by IV or IM route

• Long half-life enables once-daily dosing

• Well-tolerated with a lower risk of nephrotoxicity compared to vancomycin

• Used in serious infections including osteomyelitis, sepsis, and endocarditis

---

How It Works:

Teicoplanin inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminal of peptidoglycan precursors. This action prevents cross-linking, weakening the bacterial cell wall, leading to cell lysis and death, particularly effective in Gram-positive cocci including MRSA, MSSA, and Enterococci.

---

How to Use:

• Reconstitute the vial with sterile water for injection

• Administer by IV infusion, IV bolus, or IM injection as per physician’s instructions

• Loading dose: 400 mg every 12 hours for 3 doses, followed by 400 mg once daily (based on infection type and severity)

• Should be used under strict medical supervision in hospital settings

---

Safety Advice:

• Monitor renal function and blood counts regularly, especially during prolonged use

• Adjust dose in renal impairment

• Use cautiously in patients with known glycopeptide allergy

• Avoid rapid infusion to reduce risk of “red man syndrome”

---

Precautions:

• Not recommended for pediatric use without clinical guidance

• Inspect solution for particulate matter or discoloration before administration

• Do not mix with other drugs unless compatibility is established

• Store below 25°C; protect from light