SEFTIZOX®-SB 1.5gm Injection

Description

Composition (Per Vial):

• Ceftizoxime Sodium – 1gm

• Sulbactam Sodium – 500mg
  Form: Sterile lyophilized powder for injection
  Route of Administration: Intravenous (IV) / Intramuscular (IM)
  Pack Size: Single-dose vial
  Category: Beta-lactam Antibiotic + Beta-lactamase Inhibitor | Hospital Antibiotics

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Product Description:

SEFTIZOX®-SB 1.5gm Injection combines the third-generation cephalosporin Ceftizoxime with the beta-lactamase inhibitor Sulbactam, providing broad-spectrum antibacterial coverage, especially against beta-lactamase producing pathogens.

This synergistic combination is highly effective in treating complicated respiratory tract infections, abdominal infections, UTIs, sepsis, and post-operative infections, where resistance to standard antibiotics is suspected.

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Key Benefits:

• Broad-spectrum action against Gram-negative and Gram-positive bacteria

• Effective in polymicrobial infections, including resistant strains

• Sulbactam neutralizes beta-lactamase enzymes, enhancing efficacy of ceftizoxime

• Suitable for ICU, surgical, and hospital-acquired infection management

• Available for IV or IM administration

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How It Works:

• Ceftizoxime: A third-gen cephalosporin that inhibits bacterial cell wall synthesis

• Sulbactam: Inhibits beta-lactamase enzymes, protecting ceftizoxime from degradation

Together, they ensure enhanced antibacterial activity even against resistant organisms, offering faster and more reliable treatment outcomes.

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How to Use:

• Reconstitute with sterile water or compatible IV fluid

• Administer via slow IV infusion, IV bolus, or deep IM injection, as advised by a physician

• Dosage varies based on infection site, severity, and patient’s renal function

• For hospital use only, under supervised medical care

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Safety Advice:

• Monitor renal function, especially in elderly or renally impaired patients

• Observe for signs of hypersensitivity or superinfection during prolonged use

• Adjust dosage in renal insufficiency

• Avoid rapid IV injection

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Precautions:

• Use cautiously in patients with a history of cephalosporin or penicillin allergy

• Reconstituted solution should be used immediately or stored as per guidelines

• Do not mix with calcium-containing IV solutions (e.g., Ringer’s lactate)