IVERDEL FORTE
A Novel Antibiotic Injection to Combat Resistance....IVERDEL FORTE- is a Combination of Cefepime hydrochloride, Amikacin Sulphate along with L-Arginine available as sterile dry powder for reconstitution before use. Cefepime hydrochloride, is a semi-synthetic, broad spectrum, cephalosporin antibiotic for parenteral administration. Amikacin sulphate is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. L-Arginine at an approximate concentration of 40% is added to make them chemically compatible and control the pH of constituted solution at 4.5 to 7.5. The combination dosage form is supplied as sterile powder for IV use only.
Indications
It is Mainly indicated in the severe bacterial infections caused by the Multidrug resistant strains like
- Lower respiratory tract infections (LRTI): Nosocomial and community acquired pneumonia
- Febrile Neutropenia
- Skin and skin structure infections caused by gram negative pathogens
- Complicated intra-abdominal infections
- Bone and joint infection
- Diabetic patients undergoing surgeries
- Acute bronchitis
- Abscess
- Complicated urinary tract infections
- Surgical Procedures
- Traumatic & Accidental Cases
- Sepsis
How it works?
Amikacin stops bacterial growth by preventing the synthesis of essential proteins required by bacteria to carry out vital functions whereas Cefepime works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body.Together, they eradicate your infection effectively.
Combination - Cefepime 1000mg + Amikacin 250mg + L-Arginine 370mg Inj (Fortified with Solvent for Injection)
Adult Dose :
Iverdel Forte 1.25g twice daily over 30-60 min infusion time for 5 to 7 days Elderly Dose
These dosages do not require modification in elderly patients provided that renal and hepatic functions are satisfactory.
Impaired hepatic function - No adjustment is necessary for patients with impaired hepatic function.
Impaired renal function - There is no need to adjust dosage in the elderly unless renal impairment is present.
Cefepime component is excreted by the kidneys exclusively by filtration. Therefore, in patients with impaired renal function (creatinine clearance ≤50 ml/min), the dose of Iverdel Forte should be adjusted to compensate for the slower rate of renal elimination. The recommended initial dose of Iverdel Forte in patients with mild to moderate renal impairment should be the same as in patients with normal renal function. An estimate of creatinine clearance should be made to determine the appropriate maintenance dose.