BIONEXAPARIN® 60 Injection

Description

Composition (Per Prefilled Syringe):

• Enoxaparin Sodium – 60mg

• Strength: 60mg in 0.6ml solution

• Form: Prefilled syringe

• Route of Administration: Subcutaneous (SC)

• Category: Anticoagulant | Low Molecular Weight Heparin (LMWH) | Hospital Injectable

---

Product Description:

BIONEXAPARIN® 60 Injection delivers Enoxaparin Sodium, a low molecular weight heparin used to prevent and treat thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE). It’s also indicated in patients with unstable angina and non-Q wave myocardial infarction (MI), alongside aspirin.

Its predictable pharmacokinetics, low bleeding risk, and convenience of once or twice-daily dosing make it ideal for in-hospital and post-discharge care.

---

Key Benefits:

• Prevents life-threatening blood clots in lungs and legs

• Reduces risk of cardiovascular events in at-risk patients

• Superior bioavailability and half-life vs. unfractionated heparin

• Minimal need for lab monitoring

• Administered as a single subcutaneous injection — no infusion required

---

How It Works:

Enoxaparin enhances the action of antithrombin III, leading to inhibition of Factor Xa and Factor IIa (thrombin) — two key clotting factors. This interrupts clot formation and helps prevent complications such as DVT, PE, or secondary cardiac events.

---

How to Use:

• Inject subcutaneously, preferably in the abdominal wall or outer thigh

• Do not inject intramuscularly or intravenously

• Rotate sites with each dose

• Dose frequency and duration should be determined by a physician based on weight, renal function, and indication

• Do not expel air bubble from prefilled syringe before injection

---

Safety Advice:

• Monitor for signs of bleeding, anemia, or low platelet count (HIT)

• Regular renal monitoring recommended in elderly and renally compromised patients

• Use with caution if taking NSAIDs, aspirin, or other anticoagulants

• Discontinue at least 12–24 hours before surgery or spinal anesthesia

---

Precautions:

• Contraindicated in patients with active bleeding, hemorrhagic stroke, or history of HIT

• Caution in patients with uncontrolled hypertension or recent surgery

• Store at below 25°C, away from sunlight

• For hospital or physician-supervised home use only