MERODEL®-SB 1.5gm Injection

Description

Composition (Per Vial):

• Meropenem – 1 g

• Sulbactam Sodium – 500 mg
  Form: Lyophilized powder for IV reconstitution
  Route: Intravenous use only
  Pack: Single-use vial
  Category: Carbapenem Antibiotic | Broad-Spectrum | ICU/Resistant Infections

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Product Description:

MERODEL®-SB 1.5gm is a potent injectable formulation combining Meropenem, a broad-spectrum carbapenem antibiotic, with Sulbactam, a β-lactamase inhibitor. This powerful synergy offers enhanced coverage against ESBL-producing organisms, multidrug-resistant Gram-negative bacteria, and anaerobes.

Designed for use in critical care settings, this injection is ideal for treating severe infections such as hospital-acquired pneumonia, sepsis, intra-abdominal infections, complicated UTIs, and soft tissue infections.

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Key Benefits:

• Effective against ESBL and MDR pathogens

• Combines bactericidal power with β-lactamase inhibition

• Excellent tissue penetration, including CSF and lungs

• Ideal for ICU-grade infections and resistant bacterial strains

• Supports empirical therapy when culture reports are pending

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How It Works:

• Meropenem inhibits bacterial cell wall synthesis by binding to Penicillin-Binding Proteins (PBPs), leading to cell lysis

• Sulbactam inhibits β-lactamase enzymes, allowing meropenem to retain its efficacy against resistant organisms

Together, they deliver a broad and enhanced bactericidal action, especially in polymicrobial infections.

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How to Use:

• Reconstitute the vial with sterile water for injection or a compatible IV fluid

• Administer as slow IV infusion over 15–30 minutes

• Dosage: Varies based on infection type and severity (e.g., 1.5g every 8 hours)

• Always administer under medical supervision in a clinical setting

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Safety Advice:

• Dose adjustment required in renal impairment

• Periodic monitoring of renal and liver function is advised during prolonged use

• Use cautiously in patients with known β-lactam allergy

• Avoid mixing with other drugs in the same IV line

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Precautions:

• Do not use if solution appears cloudy or contains particles after reconstitution

• Store below 25°C; protect from light

• Reconstituted solution should be used immediately or stored in refrigerator for up to 6 hours

• Not to be used during pregnancy or lactation unless clearly indicated

• Monitor for potential CNS effects (e.g., seizures) in renally impaired patients