MERODEL®-SB 2gm Injection

Description

Composition (Per Vial):

• Meropenem – 1000 mg

• Sulbactam Sodium – 1000 mg
  Form: Lyophilized powder for IV use
  Route of Administration: Intravenous injection or infusion (Reconstitute before use)
  Pack Size: Single-use vial
  Category: Broad-Spectrum Antibiotic | ICU | Critical Infections

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Product Description:

MERODEL®-SB 2gm is an advanced combination of Meropenem, a powerful carbapenem antibiotic, and Sulbactam, a β-lactamase inhibitor. This dual combination is designed to manage high-risk, life-threatening infections caused by multi-drug resistant bacteria, especially in ICU and hospitalized patients.

The higher dose of Sulbactam (1g) offers stronger inhibition of beta-lactamase enzymes, making this formulation especially useful against resistant Gram-negative pathogens, including ESBL, Acinetobacter, and Pseudomonas species.

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Key Benefits:

• Broad-spectrum action against Gram-positive, Gram-negative, and anaerobic bacteria

• Enhanced activity against MDR and ESBL-producing strains

• Higher sulbactam concentration for superior β-lactamase inhibition

• Excellent choice for sepsis, nosocomial pneumonia, intra-abdominal infections, and complicated UTIs

• Used in empirical therapy for critically ill patients

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How It Works:

• Meropenem inhibits bacterial cell wall synthesis, causing rapid bacterial death

• Sulbactam blocks bacterial β-lactamase enzymes, protecting meropenem from degradation
  Together, they offer potent bactericidal activity, especially in resistant and polymicrobial infections.

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How to Use:

• Reconstitute the vial with sterile water for injection or suitable IV fluid

• Administer by slow IV injection (3–5 min) or IV infusion over 15–30 minutes

• Dosage should be tailored by the physician based on infection severity and renal function

• Use under strict medical supervision in hospital settings

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Safety Advice:

• Adjust dose in patients with renal impairment

• Monitor renal, liver function, and hematological parameters during extended use

• Do not mix with other IV drugs in the same line

• Watch for CNS effects in susceptible patients (e.g., seizures in renal dysfunction)

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Precautions:

• For IV use only; do not administer intramuscularly

• Reconstituted solution should be used immediately or refrigerated and used within 6 hours

• Not recommended during pregnancy or breastfeeding unless clearly indicated

• Use cautiously in patients with known allergy to β-lactam antibiotics

• Observe for any hypersensitivity reactions