METTHANS®-1GM Injection

Description

Composition (Per Vial):

• Methylprednisolone Sodium Succinate USP – 1,000 mg

• Diluent (Sterile Water for Injection) – Provided separately (optional)
  Form: Lyophilized powder for reconstitution
  Route of Administration: IM / IV
  Pack Size: 1g vial
  Category: Injectable Corticosteroid | Anti-inflammatory

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Product Description:

METTHANS®-1GM is a high-dose, fast-acting corticosteroid injection used to manage severe allergic reactions, autoimmune flares, shock, sepsis, and acute inflammation associated with various systemic conditions. It delivers rapid suppression of immune and inflammatory responses, making it suitable for emergency and intensive care use.

This formulation ensures high bioavailability, quick symptom control, and is often preferred when oral steroids are not feasible or immediate action is needed.

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Key Benefits:

• Rapid control of severe inflammation and immunologic reactions

• Ideal for autoimmune disorders, shock, acute asthma, spinal cord injury, and lupus flares

• Used in hospital emergency protocols and critical care

• Water-soluble form ensures quick systemic absorption

• Reliable in both single and multiple-dose regimens

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How It Works:

Methylprednisolone Sodium Succinate mimics natural cortisol with enhanced anti-inflammatory properties. It works by suppressing the immune response, reducing the production of pro-inflammatory cytokines, and inhibiting white blood cell migration, offering fast and effective relief from inflammation, pain, and tissue damage.

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How to Use:

• To be reconstituted with sterile water before use

• IV infusion or bolus: For emergencies like anaphylaxis or spinal cord trauma

• IM injection: For sustained systemic relief in non-urgent scenarios

• Dosing depends on condition severity and physician’s discretion

• Must be administered under strict medical supervision

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Safety Advice:

• Monitor blood pressure, blood glucose, electrolytes, and signs of infection

• Use lowest effective dose for shortest possible duration

• Gradual tapering may be required to avoid adrenal suppression

• Avoid live vaccines during treatment

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Precautions:

• Use with caution in patients with:

  • Diabetes mellitus

  • Hypertension

  • Osteoporosis

  • Peptic ulcer disease

• Contraindicated in patients with systemic fungal infections

• Long-term use may lead to Cushing’s syndrome, bone loss, or immunosuppression

• Store below 25°C; protect from moisture and light

• Discard unused solution; single-use vial