METTHANS®-500 Injection

Description

Composition (Per Vial):

• Methylprednisolone Sodium Succinate USP – 500 mg

• Water for Injection – Supplied separately for reconstitution
  Form: Sterile lyophilized powder
  Route: Intravenous (IV) or Intramuscular (IM)
  Pack Size: 500 mg vial
  Category: Corticosteroid | Anti-inflammatory | Emergency Steroid Therapy

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Product Description:

METTHANS®-500 delivers 500 mg of Methylprednisolone Sodium Succinate, designed for rapid and powerful suppression of inflammation and immune overactivity.
It is commonly used in moderate to severe allergic reactions, autoimmune flare-ups, respiratory distress, cerebral edema, and as part of emergency protocols in ICUs and surgical recovery units.

This mid-high dose is ideal for situations where oral steroid onset is too slow or systemic control is urgently required.

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Key Benefits:

• Rapid-acting glucocorticoid therapy

• Effective in treating:

  • Asthma exacerbations

  • Severe allergic responses

  • Sepsis-associated inflammation

  • Lupus, MS, or RA flares

  • Organ transplant rejection episodes

• Reliable steroid for perioperative and critical care use

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How It Works:

Methylprednisolone suppresses immune hyperactivity by inhibiting the release of pro-inflammatory cytokines, prostaglandins, and leukocyte infiltration.
It modulates the stress and immune response at the cellular level, helping restore immune balance and reduce tissue injury.

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How to Use:

• Reconstitute with sterile water before use

• IV administration preferred in emergency and hospital settings

• IM injection may be used for slower, sustained release

• Dose and frequency must be individualized by a physician

• Only for hospital/clinical use under supervision

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Safety Advice:

• Monitor vital signs, glucose levels, WBC counts, and signs of infection

• Taper gradually if used beyond a few days

• Long-term or repeated use may increase risk of adrenal suppression, osteoporosis, and immunosuppression

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Precautions:

• Contraindicated in:

  • Systemic fungal infections

  • Known corticosteroid hypersensitivity

• Caution in patients with:

  • Hypertension, diabetes, peptic ulcers, severe liver dysfunction

• Avoid concurrent use of live vaccines

• Use sterile technique to avoid contamination

• Store below 25°C; protect from moisture and direct sunlight

• Single-use vial – discard after reconstitution