PARADEL® – Paracetamol Infusion

Description

Composition (Per 100 ml):

• Paracetamol IP – 1000 mg (1.0% w/v)
  Form: Clear, sterile, ready-to-use infusion
  Route of Administration: Intravenous (slow infusion only)
  Pack Size: 100 ml plastic bottle
  Category: Analgesic | Antipyretic | IV Pain and Fever Relief

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Product Description:

PARADEL® is a sterile, non-pyrogenic intravenous formulation of Paracetamol (1000 mg), indicated for the treatment of fever and mild to moderate pain, especially in settings where oral administration is not feasible.

It is widely used in post-operative care, emergency rooms, critical care units, and for rapid fever reduction in adults and adolescents.

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Key Benefits:

• Rapid onset of action for fever and pain relief

• Bypasses gastrointestinal absorption, making it ideal for NPO (nil per os) patients

• Safer gastric profile compared to NSAIDs

• Convenient ready-to-use IV formulation

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How It Works:

Paracetamol works centrally by inhibiting prostaglandin synthesis in the brain, which helps lower fever and alleviate pain without significant anti-inflammatory action.

It has minimal gastrointestinal side effects and a low risk of bleeding, making it a preferred IV analgesic/antipyretic in clinical practice.

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How to Use:

• Administer via intravenous infusion over 15 minutes

• Adults and adolescents (>50 kg): 1000 mg (1 vial) every 6 hours (maximum 4g/day)

• Adjust dosage in underweight patients or those with hepatic impairment

• Must be used under medical supervision in a hospital or clinical setting

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Safety Advice:

• Monitor liver enzymes during prolonged use or in liver disease

• Ensure proper dilution if necessary; do not mix with other infusions

• Avoid concurrent use with other paracetamol-containing medications to prevent overdose

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Precautions:

• Contraindicated in:

  • Severe hepatic impairment or active liver disease

  • Known hypersensitivity to paracetamol

• Use with caution in patients with:

  • Chronic alcohol use, malnutrition, or dehydration

• Store below 25°C. Do not freeze

• Use immediately after opening. Single-dose only – discard unused portion