Description
Composition (Per Vial):
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Cefoperazone Sodium – 1 g
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Sulbactam Sodium – 0.5 g
Form: Dry powder for injection
Route: Intravenous (IV) / Intramuscular (IM)
Pack Size: Single-dose vial (with or without sterile water for injection)
Category: Third-Generation Cephalosporin + Beta-Lactamase Inhibitor
Product Description:
PIROZEM-PLUS® 1.5g Injection is a powerful combination of Cefoperazone, a third-generation cephalosporin, and Sulbactam, a beta-lactamase inhibitor. This formulation is specifically designed to combat moderate to severe bacterial infections, especially those caused by beta-lactamase-producing resistant strains.
It is commonly indicated for the treatment of lower respiratory tract infections, intra-abdominal infections, urinary tract infections, skin and soft tissue infections, gynecological infections, and sepsis.
Key Benefits:
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Broad-spectrum activity against resistant gram-negative and gram-positive bacteria
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Effective for hospital and post-surgical infections
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Combines bactericidal action with beta-lactamase inhibition
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Enhanced dosing for more severe or deep-seated infections
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Reliable clinical outcomes in critical care settings
How It Works:
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Cefoperazone disrupts bacterial cell wall synthesis, leading to cell death
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Sulbactam inhibits beta-lactamase enzymes that would otherwise inactivate the antibiotic
Together, they deliver synergistic action, restoring antibiotic efficacy even in resistant infections
How to Use:
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To be administered only by trained medical personnel
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Reconstitute with sterile water and administer via IV infusion or deep IM injection
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Dosage varies based on infection severity, site, and patient condition
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Frequency: Usually every 12 hours or as directed by physician
Safety Advice:
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Avoid in patients with cephalosporin or penicillin allergy
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Monitor liver function during prolonged use
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May cause mild gastrointestinal disturbances or local injection site pain
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Avoid mixing with calcium-containing solutions
Precautions:
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Use under medical supervision only
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Adjust dosage in hepatic dysfunction or dual organ failure
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Store below 25°C and protect from light
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Discard unused portion after preparation
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Do not freeze the reconstituted solution
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