PIROZEM-PLUS® 1gm Injection

Description

Composition (Per Vial):

• Cefoperazone Sodium – 500 mg

• Sulbactam Sodium – 500 mg

Form: Dry powder for injection
Route: Intravenous (IV) / Intramuscular (IM) use
Pack Size: Single-use vial (with or without sterile water, as applicable)
Category: Prescription Injectable | Cephalosporin + Beta-Lactamase Inhibitor

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Product Description:

PIROZEM-PLUS® 1gm Injection is a potent combination of Cefoperazone, a third-generation cephalosporin antibiotic, and Sulbactam, a beta-lactamase inhibitor. This formulation offers broad-spectrum bactericidal activity and is especially effective against resistant gram-negative and gram-positive bacteria.

It is commonly used in the management of hospital-acquired infections, intra-abdominal infections, lower respiratory tract infections, urinary tract infections, skin & soft tissue infections, and septicemia.

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Key Benefits:

• Effective in multi-drug resistant bacterial infections

• Broad-spectrum coverage including ESBL-producing strains

• Dual mechanism enhances treatment efficacy

• Suitable for both community and hospital-acquired infections

• Rapid onset and high tissue penetration

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How It Works:

• Cefoperazone inhibits bacterial cell wall synthesis, causing bacterial death

• Sulbactam neutralizes beta-lactamase enzymes that bacteria use to resist antibiotics
  Together, they deliver synergistic action against resistant pathogens

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How to Use:

• To be administered by qualified healthcare professionals

• Reconstitute powder with sterile water for injection

• Administer via IV slow push/infusion or deep IM route

• Dosage and frequency depend on infection severity and renal/hepatic status

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Safety Advice:

• Monitor for allergic reactions, especially in patients with beta-lactam allergy history

• Common side effects: mild diarrhea, local injection site pain, nausea

• Caution in patients with liver dysfunction

• Do not mix with calcium-containing IV fluids

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Precautions:

• Not for self-administration

• Adjust dose in hepatic and renal impairment

• Do not use if solution becomes cloudy or contains particles

• Store below 25°C, protected from moisture and light

• Discard unused portion after reconstitution