SEFTIZOX® 1gm Injection

Description

Composition (Per Vial):

• Ceftizoxime Sodium equivalent to Ceftizoxime – 1gm
  Form: Lyophilized powder for injection
  Route of Administration: Intravenous (IV) / Intramuscular (IM)
  Pack Size: Single-use vial
  Category: Antibiotic | Cephalosporin Class | Hospital Use

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Product Description:

SEFTIZOX® 1gm Injection contains Ceftizoxime, a broad-spectrum third-generation cephalosporin antibiotic, used for the treatment of moderate to severe bacterial infections in hospitalized patients. It is particularly effective against Gram-negative and some Gram-positive organisms, offering powerful coverage in infections of the respiratory tract, urinary tract, skin, and abdominal cavity.

SEFTIZOX® is known for its resistance to many β-lactamases, making it a strong choice where resistance to first-line antibiotics is suspected.

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Key Benefits:

• Broad-spectrum activity against Gram-negative pathogens

• Effective in lower respiratory tract, UTIs, gynecological, abdominal, and skin infections

• High stability against beta-lactamase enzymes

• Suitable for use in sepsis and hospital-acquired infections

• Available for both IV and IM use

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How It Works:

Ceftizoxime works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It binds to penicillin-binding proteins (PBPs) and interferes with the final step of peptidoglycan synthesis, which is crucial for bacterial cell wall integrity.

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How to Use:

• Reconstitute with the appropriate sterile diluent

• Administer via slow IV injection, IV infusion, or deep IM injection

• Dosage depends on type and severity of infection, renal function, and patient condition

• Should be administered under the supervision of a healthcare professional

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Safety Advice:

• Perform renal function tests before and during treatment, especially in elderly patients

• Use cautiously in individuals with a history of cephalosporin or penicillin allergy

• Monitor for signs of superinfection or Clostridioides difficile-associated diarrhea during extended therapy

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Precautions:

• Not recommended in patients with known hypersensitivity to cephalosporins

• Adjust dose in renal impairment

• Avoid mixing with calcium-containing IV solutions (e.g., Ringer’s or Hartmann’s)

• Use immediately after reconstitution or store as per instructions