TIGIACT® – 50mg Injection

Description

Composition (Per Vial):

• Tigecycline – 50 mg (lyophilized powder)
  Form: Sterile lyophilized powder for reconstitution
  Route of Administration: Intravenous infusion
  Pack Size: Single-use vial with sterile water for injection
  Category: Glycylcycline class | Broad-Spectrum Antibiotic | ICU-grade MDR Therapy

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Product Description:

TIGIACT® – 50mg contains Tigecycline, a glycylcycline antibiotic derived from the tetracycline class, specially designed to tackle multi-drug-resistant (MDR) bacteria. It offers broad-spectrum activity against both Gram-positive and Gram-negative organisms, including strains resistant to penicillins, cephalosporins, and carbapenems.

TIGIACT® is a preferred choice in critical care settings for infections such as complicated intra-abdominal infections (cIAI), complicated skin and soft tissue infections (cSSTI), and community-acquired pneumonia (CAP).

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Key Benefits:

• Effective against MRSA, VRE, ESBL-producing E. coli, Klebsiella, and Acinetobacter

• Used when standard therapies have failed due to antibiotic resistance

• Excellent tissue penetration, especially in lungs and abdominal sites

• Reserved for hospital-acquired and severe community infections

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How It Works:

Tigecycline inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing incorporation of amino acid residues into peptide chains. This results in a bacteriostatic effect against a broad array of bacteria, including drug-resistant strains.

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How to Use:

• Reconstitute the 50mg vial with 5.3 ml of sterile water for injection to yield a 10 mg/ml solution

• Further dilute in 100 ml of 0.9% NaCl or 5% dextrose

• Administer by IV infusion over 30 to 60 minutes

• Initial loading dose: 100 mg, followed by 50 mg every 12 hours

• Dosage adjustments may be required in severe hepatic impairment

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Safety Advice:

• Monitor liver enzymes, CBC, and renal parameters during therapy

• Not recommended for use in patients <18 years due to risk of dental discoloration

• Avoid use during pregnancy or breastfeeding unless absolutely necessary

• Ensure hospital or ICU setting for administration due to potential adverse reactions

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Precautions:

• Contraindicated in:

  • Known hypersensitivity to tetracyclines

  • Severe liver disease without dose adjustment

• Caution in:

  • Pregnant women, children, and hepatic impairment

• Possible side effects include: nausea, vomiting, anemia, elevated liver enzymes

• Do not use as first-line therapy for bloodstream infections or hospital-acquired pneumonia unless culture confirms sensitivity

• Use immediately after reconstitution or store at 2–8°C for up to 24 hours