ZAPTOMYCIN® 600 Injection

Description

Composition (Per 4 ml Ampoule):

• Clindamycin Phosphate IP – 600 mg

• Water for Injection – q.s.
  Form: Sterile solution for injection
  Route of Administration: IM / IV use
  Pack Size: 4 ml ampoule
  Category: Prescription Antibiotic Injection | Broad-Spectrum Antibacterial

---

Product Description:

ZAPTOMYCIN® 600 is a high-strength Clindamycin Phosphate Injection indicated for the treatment of moderate to severe bacterial infections caused by susceptible anaerobic and Gram-positive organisms.
This includes infections of the lower respiratory tract, intra-abdominal cavity, pelvic organs, bones, joints, skin, and soft tissues. It’s particularly beneficial when oral antibiotics are ineffective or not possible.

This 600 mg dosage ensures optimal therapeutic coverage in critically ill or hospitalized patients requiring higher systemic antibiotic levels.

---

Key Benefits:

• Highly effective against anaerobes and Gram-positive cocci

• Suitable for serious systemic infections

• Used in bone infections (osteomyelitis), intra-abdominal sepsis, pelvic inflammatory disease, and lower respiratory infections

• Trusted alternative in penicillin-allergic patients

• Administered via IM or slow IV infusion for rapid onset

---

How It Works:

Clindamycin binds to the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. This stops bacterial growth and reduces infection spread. While primarily bacteriostatic, it may be bactericidal against certain strains at higher concentrations.

---

How to Use:

• Must be administered by qualified healthcare professionals only

• IM Injection: Deep into muscle mass

• IV Use: Dilute and infuse slowly over at least 10–60 minutes

• Adult dosing: Typically 600 mg every 8–12 hours or as per physician discretion

• Always adjust dose based on weight, infection severity, and organ function

---

Safety Advice:

• Avoid rapid IV administration – may lead to hypotension or arrhythmias

• Monitor for pseudomembranous colitis (C. difficile-related diarrhea)

• Watch for pain, inflammation, or phlebitis at injection site

• Long-term use requires monitoring of liver enzymes and complete blood count (CBC)

---

Precautions:

• Contraindicated in patients with known hypersensitivity to clindamycin or lincomycin

• Use with caution in patients with hepatic impairment, GI disorders, or elderly

• Do not mix with incompatible IV fluids or medications

• Store below 25°C, protected from light

• Discard any unused portion after opening – single-use vial