Description
Composition (Each Film-Coated Tablet Contains):
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Sitagliptin Phosphate – Equivalent to Sitagliptin 100 mg
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Dapagliflozin – 10 mg
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Metformin Hydrochloride (Sustained Release) – 500 mg
Category: Diabetes Care / Triple Combination Therapy
Form: Oral Tablet
Pack Size: 10×10 Alu-Alu or Blister Pack
Product Description:
ZEMDAP® – SM 500 is a powerful triple-combination oral antidiabetic formulation containing Sitagliptin, a DPP-4 inhibitor; Dapagliflozin, an SGLT2 inhibitor; and Metformin, an insulin sensitizer. Designed for adult patients with type 2 diabetes mellitus (T2DM) who require intensive glucose control, this formulation provides multi-targeted action for managing blood sugar levels, reducing cardiovascular risk, and supporting weight and blood pressure control.
Key Benefits:
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Provides comprehensive control of fasting and postprandial glucose
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Promotes weight reduction and lowers blood pressure
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Reduces HbA1c without increasing hypoglycemia risk
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Protects cardiovascular and renal function in diabetic patients
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Convenient once-daily oral dosage for better compliance
How it works:
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Metformin lowers hepatic glucose production and improves insulin sensitivity
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Dapagliflozin blocks SGLT2 in the kidneys, leading to glucose excretion via urine
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Sitagliptin increases incretin activity, stimulating insulin release and suppressing glucagon secretion in a glucose-dependent manner
Together, they deliver synergistic blood sugar control while minimizing the risk of hypoglycemia and weight gain.
How to use:
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Take one tablet once daily, preferably with the first major meal of the day
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Swallow whole with a glass of water — do not crush or split
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Maintain adequate hydration and follow dietary guidelines
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Regularly monitor blood glucose and renal function as advised
Safety Advice:
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May cause mild gastrointestinal discomfort initially — usually subsides with continued use
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Stay hydrated to reduce the risk of urinary tract infections
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Low risk of hypoglycemia unless used with insulin or sulfonylureas
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Routine follow-ups are necessary to monitor kidney and liver function
Precautions:
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Not suitable for type 1 diabetes or diabetic ketoacidosis (DKA)
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Use with caution in patients with renal impairment, lactic acidosis risk, or pancreatitis history
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Not recommended during pregnancy or breastfeeding
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Inform your physician about all other medications being taken, especially insulin, diuretics, or cardiovascular drugs
Storage:
Store below 25°C in a cool, dry place.
Keep away from direct light and moisture.
Keep out of reach of children.
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