ZEMICOFUNG® – V Injection

Description

Composition (Per Vial):

• Voriconazole – 200 mg
  Form: Lyophilized powder for intravenous infusion
  Route of Administration: Intravenous (IV infusion only)
  Pack Size: Single-use vial
  Category: Antifungal | Triazole Antimycotic | ICU Antifungal Therapy

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Product Description:

ZEMICOFUNG® – V is an injectable formulation of Voriconazole, a broad-spectrum second-generation triazole antifungal used for the treatment of serious invasive fungal infections, including those caused by Aspergillus, Candida species, and Scedosporium.

It is considered the first-line treatment for invasive aspergillosis and is used in neutropenic patients, transplant recipients, and ICU patients at high risk for systemic fungal infections.

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Key Benefits:

• Rapid and reliable IV delivery of broad-spectrum antifungal action

• Highly effective against azole-resistant Candida and non-albicans species

• Superior tissue penetration, including CNS and pulmonary tissues

• Proven efficacy in immunocompromised and critically ill patients

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How It Works:

Voriconazole works by inhibiting fungal cytochrome P450-dependent 14α-sterol demethylase, a key enzyme involved in ergosterol synthesis, which is essential for maintaining fungal cell membrane integrity. This inhibition leads to fungal cell death.

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How to Use:

• Reconstitute the lyophilized powder with 19 ml of sterile water for injection to yield a clear solution

• Further dilute in 100 ml of 0.9% NaCl or 5% dextrose for IV infusion

• Recommended adult dosing:

  • Loading dose: 6 mg/kg every 12 hours for the first 24 hours

  • Maintenance dose: 4 mg/kg every 12 hours

• Infuse over 1–2 hours, under strict medical supervision

• Adjust dose in patients with hepatic impairment

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Safety Advice:

• Monitor liver function tests, electrolytes, and serum drug levels during therapy

• Avoid concurrent use with certain CYP3A4 substrates, like sirolimus or rifampin

• Use caution in patients with pre-existing arrhythmias or QT prolongation

• Temporary visual disturbances (blurred vision, photophobia) are common and reversible

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Precautions:

• Not for intramuscular or bolus IV injection

• Contraindicated in:

  • Known hypersensitivity to voriconazole or triazoles

  • Co-administration with certain drugs (e.g., ergot alkaloids, carbamazepine)

• Use with caution in:

  • Pregnant or breastfeeding women (only if benefit outweighs risk)

  • Hepatic and renal impairment (monitor closely)

• Avoid sunlight exposure; photosensitivity reactions have been reported

• Reconstituted solution should be used immediately or stored in the refrigerator (2–8°C) and used within 24 hours